ISSN 1662-4009 (online)

ey0017.5-11 | Novel Receptor Signaling Mechanisms | ESPEYB17

5.11. Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

PP Centeno , A Herberger , H. Mun

To read the full abstract: Nat Commun 10, 4693 (2019).In brief: A specific anion binding site senses moderate changes of inorganic phosphate levels leading to rapid inhibition of CaSR responsiveness and PTH secretion in a murine and human in vitro model system.Commentary: Phosphate sensing represents a crucial process in the regulation of ph...